NIR spectra of amine compound and its salts
Submitted by jcg2000 on 12 May 2014 - 9:51pm
Forums:
Dear All:
Can we use NIR to differentiate different salts of an amine compound, say, amphetamine sulphate, amphetamine hydrochloride, and amphetamine phosphate? Has anyone collected NIR spectra of these salts and made a comparision? It seems to me NIR should not tell the difference between the different types of salt of the same amine compound. But I do notice that these salts show different FTIR spectra. Please refer to http://www.swgdrug.org/Monographs/AMPHETAMINE.pdf for infrared spectra of the amphetamine salts. Is NIR also sensitive to the anionic part of an amine salt?
Thanks in advance!
Jerry Jin
Sheelagh Halsey
13 May 2014
I have looked at various salts, but not the particular ones you mention. One that comes to mind was a compound as a free base, hydrochloride and a tartrate, these all had significantly different spectra.
Regards
Sheelagh
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